A CHRONOBIOLOGICAL APPROACH TO CIRCULATING LEVELS OF RENIN, ANGIOTENSIN-CONVERTING ENZYME, ALDOSTERONE, ACTH, AND CORTISOL IN ADDISONS-DISEASE

被引：9

作者：

CUGINI, P ^{[1
]}

LETIZIA, C ^{[1
]}

CERCI, S ^{[1
]}

DIPALMA, L ^{[1
]}

BATTISTI, P ^{[1
]}

COPPOLA, A ^{[1
]}

SCAVO, D ^{[1
]}

机构：

[1] UNIV ROMA LA SAPIENZA, METODOL CLIN, I-00185 ROME, ITALY

来源：

CHRONOBIOLOGY INTERNATIONAL | 1993年 / 10卷 / 02期

关键词：

ADDISONS DISEASE; ADRENOCORTICOTROPIC HORMONE; ANGIOTENSIN-CONVERTING ENZYME; CIRCADIAN RHYTHM; PLASMA ALDOSTERONE; PLASMA CORTISOL; PLASMA RENIN ACTIVITY;

D O I：

10.3109/07420529309059700

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This study deals with a chronobiological approach to the circadian rhythm of the renin-angiotensin-aldosterone system (RAAS) and the ACTH-cortisol axis (ACA) in patients with Addison's disease (PAD). The aim is to explore the mechanism(s) for which the circadian rhythmicity of the RAAS and ACA takes place. The study has shown that both the RAAS and ACA are devoid of a circadian rhythm in PAD. The lack of rhythmicity for renin and ACTH provides indirect evidence that their rhythmic secretion is in some way related to the circadian oscillation of aldosterone and cortisol. This implies a new concept: a positive feedback may be included among the mechanisms which chronoregulate the RAAS and ACA.

引用

页码：119 / 122

页数：4

共 11 条

[1] ONCE-A-DAY NEURALLY STIMULATED AND BASAL ACTH SECRETION PHASES IN MAN AND THEIR RESPONSE TO CORTICOID INHIBITION [J].

CERESA, F ;

ANGELI, A ;

BOCCUZZI, G ;

MOLINO, G .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1969, 29 (08) :1074-+

[2]

Cugini P, 1985, Chronobiol Int, V2, P267, DOI 10.3109/07420528509055889

[3]

CUGINI P, 1987, GIORN GERONTOL, V35, P581

[4]

DELAPENA SS, 1982, CHRONOPHARMACOLOGY, P319

[5]

Halberg F, 1972, PHYSIOL TEACH, V1, P1

[6]

Halberg F., 1967, CELLULAR ASPECTS BIO, P20, DOI DOI 10.1007/978-3-642-88394-1

[7]

KASAHARA Y, 1981, CLIN CHEM, V27, P1114

[8] THE CRH MOTONEURON - DIFFERENTIAL PEPTIDE REGULATION IN NEURONS WITH POSSIBLE SYNAPTIC, PARACRINE, AND ENDOCRINE OUTPUTS [J].

SWANSON, LW ;

SAWCHENKO, PE ;

LIND, RW ;

RHO, JH .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1987, 512 :12-23

[9] ORGANIZATION OF OVINE CORTICOTROPIN-RELEASING FACTOR IMMUNOREACTIVE CELLS AND FIBERS IN THE RAT-BRAIN - AN IMMUNOHISTOCHEMICAL STUDY [J].

SWANSON, LW ;

SAWCHENKO, PE ;

RIVIER, J ;

VALE, WW .

NEUROENDOCRINOLOGY, 1983, 36 (03) :165-186

[10]

TOLIS G, 1979, J ENDOCRINOL INVEST, V2, P433, DOI 10.1007/BF03349346

← 1 2 →