IMMUNOTHERAPY OF TULAREMIA - CHARACTERIZATION OF A MONOCLONAL-ANTIBODY REACTIVE WITH FRANCISELLA-TULARENSIS

被引：12

作者：

NARAYANAN, RB

DRABICK, JJ

WILLIAMS, JC

FORTIER, AH

MELTZER, MS

SADOFF, JC

BOLT, CR

NACY, CA

机构：

[1] WALTER REED ARMY INST RES, DEPT CELLULAR IMMUNOL, 9620 MED CTR DR 200, ROCKVILLE, MD 20850 USA

[2] WALTER REED ARMY INST RES, DEPT BACTERIAL DIS, WASHINGTON, DC 20307 USA

[3] USA, INST INFECT DIS, DIV BACTERIOL, INTRACELLULAR PATHOGENS BRANCH, FREDERICK, MD 21701 USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 1993年 / 53卷 / 01期

关键词：

ANTIBODIES; FRANCISELLA-TULARENSIS; LIVE VACCINE STRAIN; LIPOPOLYSACCHARIDE; IMMUNOFLUORESCENCE ASSAY; ELISA;

D O I：

10.1002/jlb.53.1.112

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

An IgM monoclonal antibody (mAb) recognized surface antigens specific to Francisella tularensis wild-type (Schu4) and live vaccine strain (LVS), and reacted with both in ELISA and slide agglutination tests. This mAb also reacted with LVS microorganisms in tissues of infected mice as assessed by an indirect fluorescence technique. Western blot analysis showed the mAb to react with antigens associated with F. tularensis LPS.

引用

页码：112 / 116

页数：5

共 40 条

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