DESIGN, SYNTHESIS, AND BINDING-AFFINITY OF A NONPEPTIDE MIMIC OF SOMATOSTATIN

被引：54

作者：

PAPAGEORGIOU, C

HALTINER, R

BRUNS, C

PETCHER, TJ

机构：

[1] Sandoz Pharma Ltd. Preclinical Research

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(01)80435-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The tetrasubstituted xylofuranose 4 was synthesised as a potential nonpeptide mimic of somatostatin, based on conformational analysis of the endogenous ligand and molecular modelling studies. It displaced the radioligand [I-125-Tyr3]-octreotide with an IC50 of 23-mu-M.

引用

页码：135 / 140

页数：6

共 20 条

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