ACUTE MYELOCYTIC-LEUKEMIA ASSOCIATED WITH THROMBOCYTOSIS AND INV-3(Q21.3,Q26.2) IN A CASE OF GRONBLAND-STRANDBERG SYNDROME

Gronbland-Strandberg syndrome is an inherited connective tissue disorder with cutaneous, opthalomologic, and systemic manifestations. Here we report a case of AML with thrombocytosis arising in a patient with this syndrome. Karyotypic analysis of bone marrow cells revealed the inversion 3 (q21.3;q26.2). To our knowledge, this is the first report of the association of AML with thrombocytosis and Gronbland-Strandberg syndrome. This might be a coincidental association, but it suggests some interesting speculations regarding the pathogenesis of these diseases.