TOPICAL BETAMETHASONE-17-VALERATE INHIBITS HEAT-INDUCED VASODILATATION IN MAN

被引:3
作者
AHLUWALIA, A
FLOWER, RJ
机构
[1] Dept. of Biochemical Pharmacology, William Harvey Research Institute, St. Bartholomew's Hosp. Med. College, London EC1M 6BQ, Charterhouse Square
关键词
D O I
10.1111/j.1365-2133.1993.tb00146.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Topical betamethasone-17-valerate inhibits the vasodilatation response to local non-pathological heating of rat skin.1 We have shown that this effect can also be demonstrated in man. Topical betamethasone-17-valerate significantly inhibited the increase in human forearm cutaneous blood flow in response to heat of 44-degrees-C, as measured by laser-Doppler velocimetry. This suggests that the effects of topical steroids upon skin blood flow in the rat and in man are similar, and supports the use of the animal model as a paradigm for studying human skin blood flow, and changes in response to antiinflammatory steroids.
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页码:45 / 48
页数:4
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