THE PENTON BASE OF HUMAN ADENOVIRUS TYPE-3 HAS THE RGD MOTIF

被引：19

作者：

CUZANGE, A ^{[1
]}

CHROBOCZEK, J ^{[1
]}

JACROT, B ^{[1
]}

机构：

[1] INST BIOL STRUCT,F-38027 GRENOBLE,FRANCE

来源：

GENE | 1994年 / 146卷 / 02期

关键词：

VIRUS INTERNALIZATION; RECEPTOR; INTEGRIN; SEQUENCE;

D O I：

10.1016/0378-1119(94)90302-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The gene encoding the penton base of human adenovirus (Ad) type 3 has been sequenced. The resulting amino-acid sequence has an Arg-Gly-Asp (RGD) motif located near its middle in a hydrophilic region. The same motif is found in serotypes 2, 5 and 12. This sequence was found [Wickham et al., Cell 73 (1993) 309-319] to be involved in the internalisation of Ad2 through an interaction with some specific integrins.

引用

页码：257 / 259

页数：3

共 8 条

[1] MUTATIONS THAT ALTER AN ARG-GLY-ASP (RGD) SEQUENCE IN THE ADENOVIRUS TYPE-2 PENTON BASE PROTEIN ABOLISH ITS CELL-ROUNDING ACTIVITY AND DELAY VIRUS REPRODUCTION IN FLAT CELLS [J].