ERRATIC G-]A HYPERMUTATION WITHIN A COMPLETE CAPRINE ARTHRITIS-ENCEPHALITIS VIRUS (CAEV) PROVIRUS

被引：43

作者：

WAINHOBSON, S

SONIGO, P

GUYADER, M

GAZIT, A

HENRY, M

机构：

[1] INST COCHIN GENET MOLEC,CNRS,VPR 415,F-75014 PARIS,FRANCE

[2] CTR IMMUNOL,F-13288 MARSEILLE 9,FRANCE

[3] TEL AVIV UNIV,SACKLER SCH MED,DEPT HUMAN MICROBIOL,IL-69978 TEL AVIV,ISRAEL

来源：

VIROLOGY | 1995年 / 209卷 / 02期

关键词：

D O I：

10.1006/viro.1995.1261

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The complete nucleotide sequence of an integrated provirus of caprine arthritis-encephalitis virus (CAEV) has been determined. The provirus was defective due to extensive G --> A hypermutation. Rather than being a smooth phenomenon distributed throughout the genome it was highly erratic with hypermutated and normal regions being juxtaposed, probably reflecting local fluctuations in the intracellular dCTP pool during reverse transcription of the CAEV genome. The pattern of sequence Variation within the surface glycoproteins differs subtly from that of the primate lentiviruses. (C) 1995 Academic Press, Inc.

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页码：297 / 303

页数：7

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