The synthesis and biological evaluation of sulfamoyl nucleosides related to carbovir and AZT

被引：5

作者：

Vince, R

Pham, PT

机构：

[1] Department of Medicinal Chemistry College of Pharmacy, S.E. University of Minnesota, Minneapolis, MN 55455-0343

来源：

NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 9-10期

关键词：

D O I：

10.1080/15257779508010723

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of 5'-(O) under bar-sulfamoylated carbocyclic 2',3'-dideoxy nucleosides was synthesized and evaluated for antitumor and anti-HIN activities. In this study, we have combined the phosphate mimicking features of the sulfamoyl group with our previously reported antiviral carbocyclic nucleoside, carbovir. In a related strategy, the sufamoyl moiety was used as a replacement for the alpha-phosphate of AZT-triphosphate in an analog designed to examine a membrane permeable HIV reverse transcriptase inhibitor. Some of the analogs exhibited significant in vitro anticancer activity.

引用

页码：2051 / 2060

页数：10

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