PROLONGED SUPPRESSION OF SPERMATOGENESIS BY ESTROGEN DOES NOT PRESERVE THE SEMINIFEROUS EPITHELIUM IN PROCARBAZINE-TREATED RATS

被引:15
作者
MORRIS, ID [1 ]
BARDIN, CW [1 ]
GUNSALUS, G [1 ]
WARD, JA [1 ]
机构
[1] POPULAT COUNCIL,NEW YORK,NY
来源
INTERNATIONAL JOURNAL OF ANDROLOGY | 1990年 / 13卷 / 03期
关键词
androgen‐binding protein; cancer; cytotoxin; infertility; oestrogen; procarbazine; spermatogenesis; testis;
D O I
10.1111/j.1365-2605.1990.tb00975.x
中图分类号
R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
摘要
We examined the hypothesis that induction of reversible testicular atrophy, subsequent to withdrawal of gonadotrophin support, would alleviate the testicular toxicity of the anti‐cancer drug procarbazine. In rats, severe but reversible testicular atrophy and suppression of spermatogenesis were induced 56 days after the subcutaneous insertion of a silastic implant containing oestradiol‐17β. The effect of this treatment upon the testicular toxicity of four weekly doses of procarbazine (200 mg kg‐1) was examined 56 days after the termination of procarbazine/oestrogen treatment. At this time the testicular endocrine and sper‐matogenic functions were close to normal in rats which has received only oestra‐diol‐17β. Procarbazine produced severe testicular atrophy which was associated with azoospermia and destruction of the germinal epithelium. Serum LH and FSH concentrations were raised and were associated with low serum concentrations of both testosterone and androgen‐binding protein. The combination of procarbazine with the oestrogen treatment did not change any of the testicular toxicity and in some cases it appeared to be exacerbated. In contrast to these experiments other studies have indicated that the testis can be protected if spermatogenesis is revers‐ibly suppressed by other agents which are also active via the pituitary endocrine system. The data would therefore suggest that protection is achieved either by some testicular change other than withdrawl of pituitary gonadotrophin support or that oestradiol‐17β has additional activity which is permissive for the development of the testicular toxicity of procarbazine. Copyright © 1990, Wiley Blackwell. All rights reserved
引用
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页码:180 / 189
页数:10
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