INHIBITION OF CARNITINE PALMITOYLTRANSFERASE LEADS TO INDUCTION OF 3-HYDROXYMETHYLGLUTARYL COENZYME-A REDUCTASE-ACTIVITY IN RAT-LIVER

被引：9

作者：

JANSEN, H

VANDERLINDEN, NH

HULSMANN, WC

机构：

[1] ERASMUS UNIV,FAC MED,DEPT INTERNAL MED 3,3000 DR ROTTERDAM,NETHERLANDS

[2] ERASMUS UNIV,FAC MED,CTR THORAX,3000 DR ROTTERDAM,NETHERLANDS

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1044卷 / 03期

关键词：

(Rat liver); Cholesterol synthesis; Fatty acid oxidation; HMG-CoA reductase; Regulation;

D O I：

10.1016/0005-2760(90)90267-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The relation between carnitine palmitoyltransferase (CPT) activity and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity was investigated. Rats were treated with aminocarnitine or 1-carnitine overnight. In rats, in which CPT activity was inhibited by aminocarnitine, plasma and hepatic triacylglycerol contents were increased 5- to 6-fold. The plasma cholesterol concentration was unchanged, while the hepatic cholesterol content was lowered (-16%). Hepatic cholesterol synthesis, determined by following the incorporation of 14C-acetate and 3H2O into digitonin-precipitable sterols, in liver slices was increased 5- to 7-fold. HMG-CoA reductase activity in liver microsomes was increased to the same extent. © 1990.

引用

页码：390 / 393

页数：4

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