PATHOGENETIC ROLE FOR CALCIUM IN STUNNING

被引：30

作者：

MARBAN, E

机构：

[1] Division of Cardiology, Johns Hopkins University School of Medicine, Balttmore, MD

来源：

CARDIOVASCULAR DRUGS AND THERAPY | 1991年 / 5卷 / 05期

关键词：

CALCIUM; STUNNING; REPERFUSION; CONTRACTILE PROTEINS;

D O I：

10.1007/BF00053549

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cellular calcium homeostasis is disturbed during brief periods of ischemia, with free cytosolic Ca ([Ca2+]i) rising severalfold within 10-15 minutes (or even sooner). Nevertheless, the myocardial cells' ability to regulate Ca recovers quickly after reperfusion, unlike the lingering depression of contractile function known as stunning. This brief commentary considers the hypothesis that the rise in cell calcium during ischemia and during early reperfusion leaves behind stunning as an unwelcome legacy. This idea by no means excludes the involvement of other factors. such as free radicals; instead, it suggests a possible common pathway for cell injury by a variety of specific agents. A provocative feature of the formulation is the idea that the crucial lesion in stunning occurs at the level of the contractile proteins, rather than more proximally.

引用

页码：891 / 894

页数：4

共 21 条

[1]

Braunwald E., Kloner R.A., Myocardial reperfusion: A double-edged sword?, J Clin Invest, 76, pp. 1713-1719, (1985)

[2]

Marban E., Koretsune Y., Corretti M., Chacko V.P., Kusuoka H., Calcium and its role in myocardial cell injury during ischemia and reperfusion, Circulation, 80, pp. IV17-IV22, (1989)

[3]

Hochachka P.W., Defense strategies against hypoxia and hypothermia, Science, 231, pp. 234-241, (1986)

[4]

Malenka R.C., Kauer J.A., Zucker R.S., Nicoll R.A., Postsynaptic calcium is sufficient for potentiation of hippocampal synaptic transmission, Science, 242, pp. 81-884, (1988)

[5]

Regehr W.G., Connor J.A., Tank D.W., Optimal imaging of calcium accumulation in hippocampal pyramidal cells during synaptic activation, Nature, 341, pp. 533-536, (1989)

[6]

Marban E., Kitakaze M., Koretsune Y., Yue D.T., Chacko V.P., Pike M.M., Quantification of [Ca2+]i in perfused hearts: Critical evaluation of the 5F-BAPTA/NMR method as applied to the study of ischemia and reperfusion, Circ Res, 66, pp. 1255-1267, (1990)

[7]

Marban E., Kitakaze M., Kusuoka H., Porterfield J.K., Yue D.T., Chacko V.P., Intracellular free calcium concentration measured with 19F NMR spectroscopy in intact ferret hearts, Proc Natl Acad Sci USA, 84, pp. 6005-6009, (1987)

[8]

Steenbergen C., Murphy E., Levy L., London R.E., Elevation in cystolic free calcium concentration early in myocardial ischemia in perfused rat heart, Circ Res, 60, pp. 700-707, (1987)

[9]

Lee H-C, Smith N., Mohabir R., Clusin W.T., Cytosolic calcium transients from the beating mammalian heart, Proc Natl Acad Sci USA, 252, pp. C441-C449, (1987)

[10]

Kihara Y., Grossman W., Morgan J.P., Direct measurement of changes in intracellular calcium transients during hypoxia, ischemia, and reperfusion of the intact mammalian heart, Circ Res, 65, pp. 1029-1044, (1989)

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