CRYSTALLIZATION AND PRELIMINARY-X-RAY INVESTIGATION OF RECOMBINANT HUMAN INTERLEUKIN-4

被引：12

作者：

COOK, WJ

EALICK, SE

REICHERT, P

HAMMOND, GS

LE, HV

NAGABHUSHAN, TL

TROTTA, PP

BUGG, CE

机构：

[1] UNIV ALABAMA, DEPT PHARMACOL, BIRMINGHAM, AL 35294 USA

[2] UNIV ALABAMA, DEPT BIOCHEM, BIRMINGHAM, AL 35294 USA

[3] UNIV ALABAMA, CTR MACROMOLEC CRYSTALLOG, BIRMINGHAM, AL 35294 USA

[4] SCHERING PLOUGH CORP, RES, BLOOMFIELD, NJ 07003 USA

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1991年 / 218卷 / 04期

关键词：

D O I：

10.1016/0022-2836(91)90253-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Crystals of recombinant human interleukin 4 have been grown from solutions of ammonium sulfate. The crystals are tetragonal, space-group P41212 or P43212; the unit cell axes are a = 92.2(1) A ̊ and c = 46.4(1) A ̊. The crystals are stable to X-rays for at least three days and diffract beyond 2.8 Å resolution. The crystals contain approximately 63% solvent, assuming there is one molecule in the asymmetric unit. © 1991.

引用

页码：675 / 678

页数：4

共 36 条

[1] INTERLEUKIN-4 IS A NEUTROPHIL ACTIVATOR
BOEY, H
ROSENBAUM, R
CASTRACANE, J
BORISH, L
[J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1989, 83 (05) : 978 - 984
[2] INTERLEUKIN-4 STRONGLY AUGMENTS OR INHIBITS DNA-SYNTHESIS AND DIFFERENTIATION OF B-TYPE CHRONIC LYMPHOCYTIC-LEUKEMIA CELLS DEPENDING ON THE CO-STIMULATORY ACTIVATION AND PROGRESSION SIGNALS
CARLSSON, M
SUNDSTROM, C
BENGTSSON, M
TOTTERMAN, TH
ROSEN, A
NILSSON, K
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1989, 19 (05) : 913 - 921
[3] COFFMAN RL, 1986, J IMMUNOL, V136, P949
[4] COFFMAN RL, 1986, J IMMUNOL, V136, P4538
[5] HUMAN INTERLEUKIN-4 DOWN-REGULATES THE SURFACE EXPRESSION OF CD5 ON NORMAL AND LEUKEMIC B-CELLS
DEFRANCE, T
VANBERVLIET, B
DURAND, I
BANCHEREAU, J
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1989, 19 (02) : 293 - 299
[6] DEFRANCE T, 1988, J IMMUNOL, V141, P2000
[7] DEFRANCE T, 1987, J IMMUNOL, V139, P1135
[8] B-CELL-STIMULATORY FACTOR-I (BSF-1) PROMOTES GROWTH OF HELPER T-CELL LINES
FERNANDEZBOTRAN, R
KRAMMER, PH
DIAMANTSTEIN, T
UHR, JW
VITETTA, ES
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1986, 164 (02) : 580 - 593
[9] SECRETION CLONING VECTORS IN ESCHERICHIA-COLI
GHRAYEB, J
KIMURA, H
TAKAHARA, M
HSIUNG, H
MASUI, Y
INOUYE, M
[J]. EMBO JOURNAL, 1984, 3 (10) : 2437 - 2442
[10] GRACE MJ, 1989, 7TH P INT C IMM, P213

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