A RECEPTOR TYROSINE KINASE CDNA ISOLATED FROM A POPULATION OF ENRICHED PRIMITIVE HEMATOPOIETIC-CELLS AND EXHIBITING CLOSE GENETIC-LINKAGE TO C-KIT

被引：460

作者：

MATTHEWS, W

JORDAN, CT

GAVIN, M

JENKINS, NA

COPELAND, NG

LEMISCHKA, IR

机构：

[1] PRINCETON UNIV,DEPT MOLEC BIOL,PRINCETON,NJ 08544

[2] NCI,FREDERICK CANC RES & DEV CTR,MAMMALIAN GENET LAB,FREDERICK,MD 21702

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 20期

关键词：

HEMATOPOIETIC STEM CELL; PROTEIN-TYROSINE KINASE;

D O I：

10.1073/pnas.88.20.9026

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have cloned a receptor tyrosine kinase cDNA, designated fetal liver kinase 1 (Flk-1), from mouse cell populations enriched for hematopoietic stem and progenitor cells. Sequence analysis of this clone reveals strong homology to the c-Kit subfamily of receptor kinases, and in particular to the Flt gene product. Chromosomal mapping shows that the Flk-1, Kit, and Pdgfra genes are closely linked. Flk-1 mRNA is expressed in primitive and more mature hematopoietic cells as well as in a wide variety of nonhematopoietic tissues.

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页码：9026 / 9030

页数：5

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