ANTIBIOTIC-RESISTANCE OF ESCHERICHIA-COLI IN AUVERGNE - EPIDEMIOLOGIC DATA

The authors report 3 studies on E. coli resistance to antibacterial agents issued from several sources in the Auvergne. E. coli was isolated from 77 % (47 strains) of the community acquired upper UTI admitted in the Infectious Disease Ward from 1989 to 1994, 52.3 % of these strains were resistant to ampicilline and many had resistance to several antibacterial agents. Among bacteriemia cases collected in Moulins regional hospital (1990-1991), 77 (38.7 %) were due to E. coli : 31 were nosocomial (10 i. e. 31 % were resistant to ampicilline), 46 were community-acquired (20 i. e. 44 % were resistant to ampicilline). An intensive study of UTI E. coli strains collected from the hospital (785) and from a community laboratory connexion (2972) was performed in the Microbiology Ward at the teaching hospital of Clermont-Ferrand: the rate of strains resistant to ampicilline and to amoxicilline-clavulanate were respectively 54 % and 40 % in the hospital and 37 % and 18% in the community. Inhibitor resistant TEM (IRT) involved in resistance to amoxicilline-clavulanate occured in 4.5 % (community) and 5.8 % (hospital) of E coli clinical isolates.