PAUCI-IMMUNE NECROTIZING LUPUS NEPHRITIS - REPORT OF 2 CASES

被引:25
作者
AKHTAR, M
ALDALAAN, A
ELRAMAHI, KM
机构
[1] KING FAISAL SPECIALIST HOSP & RES CTR,DEPT PATHOL & LAB MED,RIYADH 11211,SAUDI ARABIA
[2] KING FAISAL SPECIALIST HOSP & RES CTR,DEPT MED,RIYADH 11211,SAUDI ARABIA
关键词
LUPUS; NEPHRITIS; PAUCI-IMMUNE; NECROTIZING; NONIMMUNE COMPLEX; ANTIBODY-INDEPENDENT GLOMERULAR INJURY; CELL-MEDIATED GLOMERULAR INJURY;
D O I
10.1016/S0272-6386(12)80991-7
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Two cases of pauci-immune necrotizing glomerulonephritis are presented. The glomerular lesions featured proliferative and necrotizing changes morphologically compatible with World Health Organization class III and IV lupus nephritis. However, immunofluorescent microscopy and electron microscopy failed to reveal any significant deposits of immune complexes. These findings appear to indicate that the glomerulopathy in this rare form of lupus nephritis is unrelated to the usual pathogenetic mechanism, namely, deposition of circulating or locally formed immune complexes. It is suggested that the pathogenesis of pauci-immune necrotizing lupus nephritis may involve an alternate mechanism of glomerular injury that is independent of antigen and antibody reactions and primarily involves neutrophils, lymphocytes, and monocytes. © 1994, National Kidney Foundation. All rights reserved. All rights reserved.
引用
收藏
页码:320 / 325
页数:6
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