INITIATION OF ENZYME-ALTERED FOCI BY THE SYNTHETIC STEROID CYPROTERONE-ACETATE IN RAT-LIVER FOCI BIOASSAY

被引：23

作者：

DEML, E

SCHWARZ, LR

OESTERLE, D

机构：

[1] GSF-Institutfür Toxikologie, GSF-Forschungszentrum für Umwelt and Gesundheit, D-8042 Neuherberg

来源：

CARCINOGENESIS | 1993年 / 14卷 / 06期

关键词：

D O I：

10.1093/carcin/14.6.1229

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cyproterone acetate (CPA) is a synthetic steroid which is used in oral contraceptive and anti-androgen formulations. It has previously been classified as a tumor promoter in rat liver. Recent studies have shown that CPA induces DNA repair synthesis in isolated hepatocytes, and this implies that CPA is genotoxic. We studied the initiating activity of CPA in vivo by means of a rat liver foci bioassay, using weanling female Sprague-Dawley rats. The results show that CPA induces adenosine-triphosphatase-deficient and gamma-glutamyltranspeptidase-positive putative preneoplastic foci in a dose-dependent manner. This indicates that CPA has not only promoting but also initiating activity and may therefore act as a complete carcinogen in rat liver.

引用

页码：1229 / 1231

页数：3

共 20 条

[1]

Boutwell R K, 1974, CRC Crit Rev Toxicol, V2, P419

[2]

DEGEN GH, 1987, ARCH TOXICOL S, V10, P264

[3] INDUCTION AND PROMOTION OF GAMMA-GLUTAMYLTRANSPEPTIDASE-POSITIVE FOCI IN THE LIVER OF FEMALE RATS TREATED WITH ETHINYL ESTRADIOL, CLOMIPHENE, TAMOXIFEN AND THEIR ASSOCIATIONS [J].