NOVEL SOLID-PHASE EXTRACTION STRATEGY FOR THE ISOLATION OF BASIC DRUGS FROM WHOLE-BLOOD - PRELIMINARY-STUDY USING COMMERCIALLY AVAILABLE EXTRACTION CARTRIDGES

被引：10

作者：

COSBEY, SH ^{[1
]}

CRAIG, I ^{[1
]}

GILL, R ^{[1
]}

机构：

[1] HOME OFF FORENS SCI SERV,READING RG7 4PN,BERKS,ENGLAND

来源：

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS | 1995年 / 669卷 / 02期

关键词：

D O I：

10.1016/0378-4347(95)00121-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel strategy for the solid-phase extraction of basic drugs has been developed using commercial extraction cartridges. The procedure involves the sequential application of very different isolation mechanisms, viz. hydrophobic extraction on non-porous carbon followed by ionic extraction on a strong cation exchanger. This approach to extraction achieves both high recoveries and clean extracts when analysed by GC-MS. The potential for automation has been demonstrated using commercial sample preparation equipment.

引用

页码：229 / 235

页数：7

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