INDUCTION OF TRANSCRIPTION FACTOR AP2 MESSENGER-RNA EXPRESSION IN RAT PRIMARY AFFERENT NEURONS DURING ACUTE-INFLAMMATION

被引：12

作者：

DONALDSON, LF

MCQUEEN, DS

SECKL, JR

机构：

[1] UNIV EDINBURGH, WESTERN GEN HOSP, DEPT MED, EDINBURGH EH4 2XU, MIDLOTHIAN, SCOTLAND

[2] UNIV EDINBURGH, DEPT PHARMACOL, EDINBURGH, MIDLOTHIAN, SCOTLAND

来源：

NEUROSCIENCE LETTERS | 1995年 / 196卷 / 03期

基金：

英国惠康基金;

关键词：

AP-2; MESSENGER-RNA; DORSAL ROOT GANGLION; NEUROPEPTIDE; IN SITU HYBRIDIZATION; INFLAMMATION; ADJUVANT ARTHRITIS;

D O I：

10.1016/0304-3940(95)11870-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have examined immediate early gene mRNA expression, using in situ hybridisation in innervating dorsal root ganglion (DRG) neurons following peripheral adjuvant injection. Neuronal expression of mRNAs encoding NGFI-A (nerve growth factor-induced), NGFI-B, c-jun, jun D and jun B was undetectable in untreated controls and was unchanged following adjuvant injection. AP-2 mRNA was expressed in the majority of DRG neurons in untreated controls and was significantly increased (217 +/- 43% control) 1 h after adjuvant injection. AP2 mRNA levels returned to control values by 2 h post-injection. AP-2 may form part of the early transcriptional response that induces neuropeptide gene expression in DRG after adjuvant injection.

引用

页码：181 / 184

页数：4

共 20 条

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