DEFIBRINATION WITH ANCROD IN NEPHROTOXIC NEPHRITIS IN RABBITS

被引：81

作者：

THOMSON, NM ^{[1
]}

MORAN, J ^{[1
]}

SIMPSON, IJ ^{[1
]}

PETERS, DK ^{[1
]}

机构：

[1] HAMMERSMITH HOSP, ROY POSTGRAD MED SCH, DEPT MED, LONDON W12 0HS, ENGLAND

来源：

KIDNEY INTERNATIONAL | 1976年 / 10卷 / 05期

关键词：

D O I：

10.1038/ki.1976.120

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

In rabbits with nephrotoxic nephritis, defibrination with ancrod [Malayan pitviper venom] provided protection when administered during the autologous phase, after extensive glomerular fibrin depostion had occurred and crescents and renal failure were developing. When further glomerular fibrin deposition was prevented by defibrination, deposited fibrin was rapidly removed, indicating that glomerular fibrin-clearing mechanisms are retained in crescentic nephritis. Defibrination had no effect on the extent of glomerular C3 [complement component 3] deposition or on the amount of proteinuria.

引用

页码：343 / 347

页数：5

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