INITIAL SENSITIVITY, ACUTE TOLERANCE AND ALCOHOL-CONSUMPTION IN 4 INBRED STRAINS OF RATS

被引：29

作者：

KHANNA, JM ^{[1
]}

KALANT, H ^{[1
]}

CHAU, AK ^{[1
]}

SHARMA, H ^{[1
]}

机构：

[1] ADDICT RES FDN,TORONTO M5S 2S1,ONTARIO,CANADA

来源：

PSYCHOPHARMACOLOGY | 1990年 / 101卷 / 03期

关键词：

Acute tolerance; Drinking; Rat; Sensitivity; Strains;

D O I：

10.1007/BF02244059

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Initial sensitivity and acute tolerance to ethanol were determined in a jumping test in separate groups of spontaneously hypertensive (SH) and normotensive Wistar-Kyoto (WKY) rats, and of Dahl salt-sensitive (SS) and salt-resistant (SR) rats. One week later, voluntary consumption of ethanol was studied in all groups. SH rats were found to be more sensitive than WKY, but there was no difference in acute tolerance development between these two strains. SH rats, however, drank significantly more alcohol than the WKY in both the two-bottle choice paradigm and the limited access model. Similarly, SS rats drank significantly more alcohol than the SR rats, although SS rats were found to be more sensitive to ethanol than SR. There was again no difference in acute tolerance development between these two strains. These observations suggest that difference in alcohol consumption in these strains cannot be accounted for by significant differences in acute tolerance or in initial sensitivity to ethanol. © 1990 Springer-Verlag.

引用

页码：390 / 395

页数：6

共 16 条

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[2]

Cappell H., 1981, RES ADV ALCOHOL DRUG, V6, P159

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