INHIBITION OF HEPATIC LIPASE ACTIVITY IMPAIRS CHYLOMICRON REMNANT-REMOVAL IN RATS

被引：101

作者：

SULTAN, F

LAGRANGE, D

JANSEN, H

GRIGLIO, S

机构：

[1] INST BIOMED CORDELIERS,PHYSIOPATHOL NUTR LAB,INSERM,U177,15 RUE ECOLE MED,F-75006 PARIS,FRANCE

[2] ERASMUS UNIV,DEPT BIOCHEM 1,3000 DR ROTTERDAM,NETHERLANDS

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1042卷 / 01期

关键词：

(Rat); Chylomicron remnant; Hepatic lipase; Inhibition; Liver;

D O I：

10.1016/0005-2760(90)90071-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[4-14C]Cholesteryl oleyl ether-labeled chylomicron remnants were injected into rats which received a specific goat antibody against rat hepatic lipase or a control serum. Chylomicron remnant cholesterol ether disappeared from circulation with a significantly higher half-life (2-fold) in antibody-treated rats than in controls (P < 0.001). Recovered radioactivity in the liver was 2-fold lower in antibody-treated rats (22.8% (n = 6) vs. 45% (n = 4) P < 0.01). These results clearly show that hepatic lipase may strongly promote chylomicron remnant cholesterol ether uptake by the liver. © 1990.

引用

页码：150 / 152

页数：3

共 22 条

[1] HEPATIC-UPTAKE OF PHOSPHOLIPID-DEPLETED CHYLOMICRONS INVIVO - COMPARISON WITH THE UPTAKE OF CHYLOMICRON REMNANTS [J].