ACUTE EFFECTS OF SINGLE AND REPEATED ELECTROCONVULSIVE-THERAPY ON PLASMA-CATECHOLAMINES AND BLOOD-PRESSURE IN MAJOR DEPRESSIVE DISORDER

被引：26

作者：

MANN, JJ

MANEVITZ, AZA

CHEN, JS

JOHNSON, KS

ADELSHEIMER, EF

AZIMAHELLER, R

MASSINA, A

WILNER, PJ

机构：

[1] CORNELL UNIV,MED CTR,COLL MED,PSYCHIAT,NEW YORK,NY 10021

[2] NEW YORK STATE DEPT HLTH,ALBANY,NY 12201

[3] STANFORD UNIV,STANFORD,CA 94305

[4] CORNELL UNIV,MED CTR,COLL MED,ANESTHESIOL,NEW YORK,NY 10021

[5] CORNELL UNIV,MED CTR,COLL MED,PSYCHIAT,NEW YORK,NY 10021

来源：

PSYCHIATRY RESEARCH | 1990年 / 34卷 / 02期

关键词：

blood pressure; Electroconvulsive therapy; heart rate; major depressive episode; plasma catecholamines;

D O I：

10.1016/0165-1781(90)90014-V

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The role of activation of adrenergic neurons by electroconvulsive therapy (ECT) in its antidepressant action was studied by examining acute sympathetic nervous system (SNS) responses to ECT during a course of treatment in patients with melancholia. ECT had an acute dose-dependent effect on plasma norepinephrine (NE) level and blood pressure. The postictal increase in plasma NE and blood pressure was independent of electrical seizure duration. Acute levels of NE and epinephrine after ECT correlated positively with ECT dosage. No cumulative effect of repeated ECT was found on the SNS responses. ECT does activate the SNS in a dose-dependent fashion. However, alternative strategies seem necessary for studying the action of ECT on noradrenergic neurons to identify effects that are cumulative, correspond more closely to the time course of its antidepressant action, and correlate with clinical outcome. © 1990.

引用

页码：127 / 137

页数：11

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