MINOCYCLINE-INDUCED ORAL PIGMENTATION

被引：38

作者：

SILLER, GM ^{[1
]}

TOD, MA ^{[1
]}

SAVAGE, NW ^{[1
]}

机构：

[1] UNIV QUEENSLAND, FAC DENT, BRISBANE, QLD, AUSTRALIA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1994年 / 30卷 / 02期

关键词：

D O I：

10.1016/S0190-9622(94)70038-9

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Oral mucosal pigmentation is an infrequently reported side effect of minocycline. Two patients with minocycline deposition within teeth and bone, demonstrated by fluoresence microscopy, are described. Minocycline is the only tetracycline reported to cause discoloration of the oral mucosa. This may be the result of deposition of an insoluble degradation product of minocycline in the underlying bone. Pigmentation is not necessarily dose-dependent and may take months or years to resolve.

引用

页码：350 / 354

页数：5

共 41 条

[1]

ANGELONI VL, 1987, CUTIS, V40, P229

[2] MINOCYCLINE-RELATED CUTANEOUS HYPERPIGMENTATION AS DEMONSTRATED BY LIGHT-MICROSCOPY, ELECTRON-MICROSCOPY AND X-RAY-ENERGY SPECTROSCOPY [J].