POSTMORTEM DIAGNOSIS OF ACUTE ANAPHYLAXIS BY SERUM TRYPTASE ANALYSIS - A CASE-REPORT

被引:51
作者
ANSARI, MQ
ZAMORA, JL
LIPSCOMB, MF
机构
[1] SW INST FORENS SCI,DALLAS,TX
[2] PARKLAND MEM HOSP & AFFILIATED INST,DALLAS,TX 75235
关键词
ANAPHYLAXIS; TRYPTASE; POSTMORTEM; MAST CELL;
D O I
10.1093/ajcp/99.1.101
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Systemic anaphylaxis is an acute allergic emergency resulting from generalized mast cell degranulation. In the United States, it is estimated that anaphylaxis accounts for about 500 deaths each year. Hymenoptera-sting hypersensitivity is one of the most common causes of systemic anaphylaxis. The authors report a case of a healthy 26-year-old man who developed acute anaphylaxis after a bee sting, could not be resuscitated, and died within 1 hour. At autopsy, performed 14 hours after the event, the only pathologic findings were laryngeal edema and congestion of lung. Postmortem tryptase levels in the blood were obtained and were instrumental in confirming a diagnosis of acute anaphylaxis. This case is reported to discuss the difficulties associated with using traditional histamine levels in making a diagnosis of anaphylaxis and to validate the value of using tryptase levels to document acute anaphylaxis as a cause of death, even when serum is not obtained until many hours after death.
引用
收藏
页码:101 / 103
页数:3
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