AN ENANTIOSELECTIVE APPROACH TO RING A OF TAXOL USING THE WIELAND-MIESCHER KETONE

被引：19

作者：

GOLINSKI, M

VASUDEVAN, S

FLORESCA, R

BROCK, CP

WATT, DS

机构：

[1] UNIV KENTUCKY,DEPT CHEM,LEXINGTON,KY 40506

[2] UNIV KENTUCKY,DIV PHARMACEUT & MED CHEM,LEXINGTON,KY 40506

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 01期

关键词：

D O I：

10.1016/S0040-4039(00)60056-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The selective protection of the S-(+)-enantiomer of the Wieland Miescher ketone (2) as the tertbutyldimethylsilyl-protected cyanohydrin 7 and the oxidative cleavage of an alpha-ketol 8 that was derived from 7 provided a model 10 for the A ring of the taxol (1) possessing the correct C-1 stereochemistry of taxol and functionality suitable for further elaboration.

引用

页码：55 / 58

页数：4

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