MORPHINE-INDUCED MODIFICATION OF QUININE PALATABILITY - EFFECTS OF MULTIPLE MORPHINE-QUININE TRIALS

被引：19

作者：

CLARKE, SNDA ^{[1
]}

PARKER, LA ^{[1
]}

机构：

[1] WILFRID LAURIER UNIV, DEPT PSYCHOL, WATERLOO, ON N2L 3C5, CANADA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1995年 / 51卷 / 2-3期

关键词：

MORPHINE; PALATABILITY; QUININE; TASTE; TASTE REACTIVITY; INGESTION; REWARD;

D O I：

10.1016/0091-3057(95)00042-U

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Morphine pretreatment attenuates aversive taste reactions elicited by quinine solution when assessed by the taste reactivity test. To determine whether this effect changes across trials, rats were administered morphine (2 mg/kg, subcutaneously) 30 min before a 5-min intraoral infusion of quinine solution (0.05%) on each of eight trials. Neither tolerance nor sensitization developed to morphine-induced attenuation of quinine aversiveness; morphine suppressed quinine-elicited aversive reactions on each trial. In addition, when tested in the absence of morphine, rats displayed a reduced aversion to quinine, suggesting that quinine became conditionally less aversive following previous pairings with morphine.

引用

页码：505 / 508

页数：4

共 12 条

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