PSEUDODISTOMIN-C, A NEW PIPERIDINE ALKALOID WITH UNUSUAL ABSOLUTE-CONFIGURATION FROM THE OKINAWAN TUNICATE PSEUDODISTOMA-KANOKO

被引：47

作者：

KOBAYASHI, J

NAITOH, K

DOI, Y

DEKI, K

ISHIBASHI, M

机构：

[1] Faculty of Pharmaceutical Sciences, Hokkaido University

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1995年 / 60卷 / 21期

关键词：

D O I：

10.1021/jo00126a053

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pseudodistomin C, a new cytotoxic piperidine alkaloid, was isolated from the Okinawan tunicate Pseudodistoma kanoko and the structure elucidated by spectral data, chemical degradations, and synthesis. The absolute configurations of the C-4 and C-5 chiral centers of pseudodistomin C were revealed by chiral HPLC analysis to be 4S and 5R, which were opposite to those of pseudodistomins A and B, previously isolated from the same tunicate, having the same planar structure as to the piperidine nucleus.

引用

页码：6941 / 6945

页数：5

共 21 条

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