THYMIC EPITHELIAL CELL-DERIVED SUPERNATANTS SUSTAIN THE MATURATION OF HUMAN PROTHYMOCYTES - INVOLVEMENT OF INTERLEUKIN-1 AND CD23

被引：15

作者：

DALLOUL, AH ^{[1
]}

FOURCADE, C ^{[1
]}

DEBRE, P ^{[1
]}

MOSSALAYI, MD ^{[1
]}

机构：

[1] CHU PITIE SALPETRIERE,IMMUNOL LAB,IMMUNOHEMATOL MOLEC GRP,CNRS,URA 625,F-75634 PARIS 13,FRANCE

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1991年 / 21卷 / 10期

关键词：

D O I：

10.1002/eji.1830211050

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During their development, human CD7+ lymphoid stem cells migrate into the thymus where, following intimate contact with thymic tissue, they proliferate and differentiate into functionally mature T lymphocytes. In this study, we investigated the effect of thymic epithelial cell-derived supernatants (TEC-SN) on early CD7+CD2-CD3- thymocytes. Our results indicate that TEC-SN are able to promote CD2 and CD3/TcR alpha/beta expression by CD7+ precursors. This activity correlated with soluble CD23 and interleukin 1 levels in TEC-SN. Furthermore, monoclonal antibodies to these cytokines decreased in vitro maturation of prothymocytes. Thus, in addition to cell-cell interactions, human TEC produce cytokines able to support early steps of thymocyte differentiation.

引用

页码：2633 / 2636

页数：4

共 23 条

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