PROLONGED ACCUMULATION OF DIAZEPAM IN OBESITY

被引：72

作者：

ABERNETHY, DR

GREENBLATT, DJ

DIVOLL, M

SHADER, RI

机构：

[1] TUFTS UNIV,SCH MED,DEPT PSYCHIAT,DIV CLIN PHARMACOL,BOSTON,MA 02111

[2] TUFTS UNIV,SCH MED,DEPT MED,DIV CLIN PHARMACOL,BOSTON,MA 02111

[3] NEW ENGLAND MED CTR,BOSTON,MA 02111

来源：

JOURNAL OF CLINICAL PHARMACOLOGY | 1983年 / 23卷 / 8-9期

关键词：

D O I：

10.1002/j.1552-4604.1983.tb02750.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：369 / 376

页数：8

共 14 条

[1] PROLONGATION OF DRUG HALF-LIFE DUE TO OBESITY - STUDIES OF DESMETHYLDIAZEPAM (CLORAZEPATE) [J].

ABERNETHY, DR ;

GREENBLATT, DJ ;

DIVOLL, M ;

SHADER, RI .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1982, 71 (08) :942-944

[2]

ABERNETHY DR, 1981, J PHARMACOL EXP THER, V217, P681

[3]

BRAY GA, 1979, DM-DIS MON, V26, P7

[4] BINDING OF DIAZEPAM AND DESMETHYLDIAZEPAM TO PLASMA-PROTEIN - CONCENTRATION-DEPENDENCE AND INTERACTIONS [J].

DIVOLL, M ;

GREENBLATT, DJ .

PSYCHOPHARMACOLOGY, 1981, 75 (04) :380-382

[5]

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[6] DRUG-THERAPY - CLINICAL PHARMACOKINETICS .1. [J].

GREENBLATT, DJ ;

KOCHWESER, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1975, 293 (14) :702-705

[7] DETERMINATION OF DESMETHYLDIAZEPAM IN PLASMA BY ELECTRON-CAPTURE GLC - APPLICATION TO PHARMACOKINETIC STUDIES OF CLORAZEPATE [J].

GREENBLATT, DJ .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1978, 67 (03) :427-429

[8] DRUG-THERAPY - CLINICAL PHARMACOKINETICS .2. [J].

GREENBLATT, DJ ;

KOCHWESER, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1975, 293 (19) :964-970

[9]

GREENBLATT DJ, 1978, CLIN CHEM, V24, P1838

[10] AN ALGORITHM FOR LEAST-SQUARES ESTIMATION OF NONLINEAR PARAMETERS [J].

MARQUARDT, DW .

JOURNAL OF THE SOCIETY FOR INDUSTRIAL AND APPLIED MATHEMATICS, 1963, 11 (02) :431-441

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