THE C-MYC-REGULATED GENE-MR1 ENCODES PLASMINOGEN-ACTIVATOR INHIBITOR-1

被引：148

作者：

PRENDERGAST, GC ^{[1
]}

DIAMOND, LE ^{[1
]}

DAHL, D ^{[1
]}

COLE, MD ^{[1
]}

机构：

[1] PRINCETON UNIV,DEPT BIOL,LEWIS THOMAS LAB,PRINCETON,NJ 08544

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 03期

关键词：

D O I：

10.1128/MCB.10.3.1265

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The DNA sequence of the c-myc-regulated gene mr1 (G.C. Prendergast and M.D. Cole, Mol. Cell. Biol. 9:124-134, 1989) reveals that it encodes plasminogen activator inhibitor 1 (PAI-1), a regulator of extracellular proteolysis. Comparison of the human and mouse PAI-1 promoters and cDNA 3' noncoding regions revealed several highly conserved sequence domains, potential targets for c-myc and other factors influencing PAI-1 expression. We discuss possible roles for PAI-1 in normal and neoplastic cell growth control.

引用

页码：1265 / 1269

页数：5

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