ACYLIMIDAZOLIDES AS VERSATILE SYNTHETIC INTERMEDIATES FOR THE PREPARATION OF STERICALLY CONGESTED AMIDES AND KETONES - A PRACTICAL SYNTHESIS OF PROSCAR

被引：7

作者：

BHATTACHARYA, A

WILLIAMS, JM

AMATO, JS

DOLLING, UH

GRABOWSKI, EJJ

机构：

[1] Merck Sharp & Dohme Research Labaoratories, Process Research Department, 2000 Rahway, N. J.

来源：

SYNTHETIC COMMUNICATIONS | 1990年 / 20卷 / 17期

关键词：

D O I：

10.1080/00397919008051477

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Acylimidazolides react with magnesium amides to produce car-boxamides in excellent yields, whereas Fe(III) catalyzed cross coupling between acylimidazolide and Grignard reagents produce ketones in high yields. These methods were utilized to prepare the a-reductase inhibitor Proscar® as well as various 17β-amide and ketone analogs of Δ1-4-aza-5α-androsten-3-one. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：2683 / 2690

页数：8

共 20 条

[1] SILYLATION-MEDIATED OXIDATION OF 4-AZA-3-KETOSTEROIDS WITH DDQ PROCEEDS VIA DDQ-SUBSTRATE ADDUCTS [J].