THE RENAL GROWTH-HORMONE INSULIN-LIKE GROWTH-FACTOR I AXIS

被引：5

作者：

HAMMERMAN, MR

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT INTERNAL MED & CELL BIOL & PHYSIOL,DIV RENAL,ST LOUIS,MO 63110

[2] WASHINGTON UNIV,SCH MED,DEPT INTERNAL MED & CELL BIOL & PHYSIOL,DIV ENDOCRINE,ST LOUIS,MO 63110

来源：

AMERICAN JOURNAL OF KIDNEY DISEASES | 1991年 / 17卷 / 06期

关键词：

COLLECTING DUCT; COMPENSATORY HYPERTROPHY; HYPERSOMATOTROPISM; SOMATOMEDIN; SOMATOTROPIN;

D O I：

10.1016/S0272-6386(12)80341-6

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Collecting duct is a major site of insulin-like growth factor-I (IGF-I) synthesis within kidney. Production of IGF-I at this site is stimulated by growth hormone (GH). IGF-I produced in collecting duct is likely to act on glomerulus and proximal tubule via IGF-I receptors present at these locations. Renal IGF-I may be causative of the glomerular and proximal tubular hypertrophy that occurs in hypersomatotropic states, of compensatory renal hypertrophy, and of renal regeneration following acute ischemic injury. © 1991, National Kidney Foundation, Inc.. All rights reserved.

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页码：644 / 646

页数：3

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