MRI SUSCEPTOMETRY - IMAGE-BASED MEASUREMENT OF ABSOLUTE SUSCEPTIBILITY OF MR CONTRAST AGENTS AND HUMAN BLOOD

We present a novel NMR imaging technique that allows absolute determination of the magnetic susceptibility constant, χ, of a solution. By comparing the phase difference of MR images produced with an instant (echo planar) “offset” spin‐echo sequence, we obtain a direct measure of the magnetic field perturbations caused by the solution. We demonstrate this method with Gd(DTPA), Dy(DTPA), human red blood cells, and superparamagnetic iron oxide particles. © 1992 Academic Press, Inc. Copyright © 1992 Wiley‐Liss, Inc., A Wiley Company