L-CYSTEINE AUGMENTS THE VASORELAXATION INDUCED BY SODIUM-NITRITE AND SIN-1 BUT NOT THAT DUE TO ACETYLCHOLINE

被引：11

作者：

ARVOLA, P ^{[1
]}

PORSTI, I ^{[1
]}

VUORINEN, P ^{[1
]}

HUHTALA, H ^{[1
]}

METSAKETELA, T ^{[1
]}

VAPAATALO, H ^{[1
]}

机构：

[1] UNIV TAMPERE,DEPT PUBL HLTH,SF-33101 TAMPERE,FINLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 214卷 / 2-3期

基金：

芬兰科学院;

关键词：

ACETYLCHOLINE; CGMP; L-CYSTEINE; SIN-1 (3-MORPHOLINOSYDNONIMINE); SODIUM NITRITE; VASCULAR SMOOTH MUSCLE RELAXATION;

D O I：

10.1016/0014-2999(92)90133-O

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of 1 mM L-cysteine on sodium nitrite-, 3-morpholinosydnonimine (SIN-1)- and acetylcholine-induced relaxation and cyclic GMP accumulation were studied in isolated noradrenaline-precontracted rat mesenteric arterial rings. L-Cysteine augmented the relaxation and cyclic GMP increase induced by sodium nitrate and SIN-1 but not those induced by acetylcholine. The effects of L-cysteine on relaxation were independent of the presence of intact endothelium. The results suggest that L-cysteine protects exogenously released nitric oxide.

引用

页码：289 / 292

页数：4

共 11 条

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