A SPECIFIC T-CELL RECEPTOR GENOTYPE PREFERENCE IN THE IMMUNE-RESPONSE TO A SYNTHETIC PLASMODIUM-FALCIPARUM MALARIA VACCINE

被引：21

作者：

MURILLO, LA

TENJO, FA

CLAVIJO, OP

OROZCO, MA

SAMPAIO, S

KALIL, J

PATARROYO, ME

机构：

[1] UNIV NACL COLOMBIA, HOSP SAN JUAN DIOS, INST INMUNOL, BOGOTA, COLOMBIA

[2] UNIV SAO PAULO, ESCUELA MED, SAO PAULO, BRAZIL

来源：

PARASITE IMMUNOLOGY | 1992年 / 14卷 / 01期

关键词：

TCR; PLASMODIUM-FALCIPARUM MALARIA; IMMUNE RESPONSE; MALARIA VACCINE;

D O I：

10.1111/j.1365-3024.1992.tb00008.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In recent studies with 63 and 122 volunteers vaccinated with the SPf66 synthetic malaria vaccine, specific antibody patterns were classified as high or low responders. Using the Polymerase Chain Reaction (PCR), a specific and selective preference was shown for the V-beta arrangement of the T-cell receptor in the high responder group involving the V-beta-8 gene. The low responder group showed the rearrangement of a different set of genes, and a particular association with V-beta-10.

引用

页码：87 / 94

页数：8

共 20 条

[1] ERLICH HA, 1989, PCR TECHNOLOGY, pCH15
[2] Gait M. J, 1984, OLIGONUCLEOTIDE SYNT
[3] Hedrick S. M., 1989, Fundamental immunology., P291
[4] HEWITT CRA, 1989, J IMMUNOL, V142, P1429
[5] PREFERENTIAL EXPRESSION OF A DEFINED T-CELL RECEPTOR BETA-CHAIN GENE IN HAPTEN-SPECIFIC CYTOTOXIC T-CELL CLONES
HOCHGESCHWENDER, U
WELTZIEN, HU
EICHMANN, K
WALLACE, RB
EPPLEN, JT
[J]. NATURE, 1986, 322 (6077) : 376 - 378
[6] V-BETA-SPECIFIC STIMULATION OF HUMAN T-CELLS BY STAPHYLOCOCCAL TOXINS
KAPPLER, J
KOTZIN, B
HERRON, L
GELFAND, EW
BIGLER, RD
BOYLSTON, A
CARREL, S
POSNETT, DN
CHOI, YW
MARRACK, P
[J]. SCIENCE, 1989, 244 (4906) : 811 - 813
[7] A T-CELL RECEPTOR VBETA-SEGMENT THAT IMPARTS REACTIVITY TO A CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX PRODUCT
KAPPLER, JW
WADE, T
WHITE, J
KUSHNIR, E
BLACKMAN, M
BILL, J
ROEHM, N
MARRACK, P
[J]. CELL, 1987, 49 (02) : 263 - 271
[8] THE MOLECULAR-GENETICS OF THE T-CELL ANTIGEN RECEPTOR AND T-CELL ANTIGEN RECOGNITION
KRONENBERG, M
SIU, G
HOOD, LE
SHASTRI, N
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1986, 4 : 529 - 591
[9] MOLECULAR ANALYSIS OF HLA DR4-BETA-1 GENE IN MALARIA VACCINEES - TYPING AND SUBTYPING BY PCR TECHNIQUE AND OLIGONUCLEOTIDES
MURILLO, LA
ROCHA, CL
MORA, AL
KALIL, J
GOLDENBERG, AK
PATARROYO, ME
[J]. PARASITE IMMUNOLOGY, 1991, 13 (02) : 201 - 210
[10] GENETIC-CONTROL OF THE IMMUNE-RESPONSE TO A SYNTHETIC VACCINE AGAINST PLASMODIUM-FALCIPARUM
PATARROYO, ME
VINASCO, J
AMADOR, R
ESPEJO, F
SILVA, Y
MORENO, A
ROJAS, M
MORA, AL
SALCEDO, M
VALERO, V
GOLDBERG, AK
KALIL, J
[J]. PARASITE IMMUNOLOGY, 1991, 13 (05) : 509 - 516

← 1 2 →