HEMATOPOIETIC REGULATORS

被引：49

作者：

METCALF, D

机构：

[1] Institute of Medical Research, PO Royal Melbourne Hospital, 3050 Vic., The Walter and Eliza Hall

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1992年 / 17卷 / 08期

关键词：

D O I：

10.1016/0968-0004(92)90436-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The production and maturation of blood cells from the eight major blood cell lineages is a complex and continuous process, which is largely controlled by specific glycoprotein hemopoietic regulators. These regulators also control the functional activity of the blood cells through eliciting a diverse set of intracellular responses initiated by a regulator-specific membrane receptor. Twenty of these regulators have now been characterized, and their mass production has led to four already being licensed for clinical use in disease states involving subnormal blood cell formation.

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页码：286 / 289

页数：4

相关论文

共 26 条

[1] HEMATOPOIETIC RECEPTORS AND HELICAL CYTOKINES [J].

BAZAN, JF .

IMMUNOLOGY TODAY, 1990, 11 (10) :350-354

[2] STRUCTURAL DESIGN AND MOLECULAR EVOLUTION OF A CYTOKINE RECEPTOR SUPERFAMILY [J].

BAZAN, JF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (18) :6934-6938

[3] GROWTH OF MOUSE BONE MARROW CELLS IN VITRO [J].

BRADLEY, TR ;

METCALF, D .

AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE, 1966, 44 :287-&

[4] THE PROTO-ONCOGENE C-KIT ENCODING A TRANSMEMBRANE TYROSINE KINASE RECEPTOR MAPS TO THE MOUSE W-LOCUS [J].

CHABOT, B ;

STEPHENSON, DA ;

CHAPMAN, VM ;

BESMER, P ;

BERNSTEIN, A .

NATURE, 1988, 335 (6185) :88-89

[5] LONG-TERM EXPOSURE TO RETROVIRALLY EXPRESSED GRANULOCYTE-COLONY-STIMULATING FACTOR INDUCES A NONNEOPLASTIC GRANULOCYTIC AND PROGENITOR-CELL HYPERPLASIA WITHOUT TISSUE-DAMAGE IN MICE [J].

CHANG, JM ;

METCALF, D ;

GONDA, TJ ;

JOHNSON, GR .

JOURNAL OF CLINICAL INVESTIGATION, 1989, 84 (05) :1488-1496

[6]

CHANG JM, 1989, BLOOD, V73, P1487

[7]

DAVIS I, 1991, SEMIN HEMATOL, V28, P25

[8] CORRECTION OF THE ANEMIA OF END-STAGE RENAL-DISEASE WITH RECOMBINANT-HUMAN-ERYTHROPOIETIN - RESULTS OF A COMBINED PHASE-I AND PHASE-II CLINICAL-TRIAL [J].

ESCHBACH, JW ;

EGRIE, JC ;

DOWNING, MR ;

BROWNE, JK ;

ADAMSON, JW .

NEW ENGLAND JOURNAL OF MEDICINE, 1987, 316 (02) :73-78

[9] MOLECULAR-CLONING OF CDNA FOR MURINE INTERLEUKIN-3 [J].

FUNG, MC ;

HAPEL, AJ ;

YMER, S ;

COHEN, DR ;

JOHNSON, RM ;

CAMPBELL, HD ;

YOUNG, IG .

NATURE, 1984, 307 (5948) :233-237

[10]

GLASPY JA, 1990, EXP HEMATOL, V18, P1137