HUMAN APOLIPOPROTEIN-A-I GENE-EXPRESSION INCREASES HIGH-DENSITY-LIPOPROTEIN AND SUPPRESSES ATHEROSCLEROSIS IN THE APOLIPOPROTEIN E-DEFICIENT MOUSE

被引：512

作者：

PLUMP, AS ^{[1
]}

SCOTT, CJ ^{[1
]}

BRESLOW, JL ^{[1
]}

机构：

[1] ROCKEFELLER UNIV, NEW YORK, NY 10021 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 20期

关键词：

D O I：

10.1073/pnas.91.20.9607

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Atherosclerosis is a complex disease with both genetic and environmental determinants. Apolipoprotein (Apo) E-deficient mice have been created that are highly susceptible to atherosclerosis. In order to assess the role of human apolipoprotein (hApo) A-I and high density lipoprotein (HDL) in atherosclerosis susceptibility, transgenic mice overexpressing the hApo A-I gene were crossed with Apo E-deficient mice. Apo E -/-, hApo A-I mice with two fold elevation in HDL cholesterol have markedly diminished atherosclerosis with less fibroproliferative lesions by 8 months of age. A strong reciprocal relationship between HDL cholesterol levels and atherosclerosis was found with HDL levels accounting for 78% of the observed variance in mean lesion area. The effect of HDL on atherosclerosis resistance was independent of non-HDL cholesterol.

引用

页码：9607 / 9611

页数：5

共 20 条

[1] REGRESSION OF ATHEROSCLEROTIC LESIONS BY HIGH-DENSITY-LIPOPROTEIN PLASMA FRACTION IN THE CHOLESTEROL-FED RABBIT [J].