RETENTION OF CEREBROVASCULAR DILATION AFTER CORTICAL SPREADING DEPRESSION IN ANESTHETIZED RABBITS

被引:81
作者
BUSIJA, DW [1 ]
MENG, W [1 ]
机构
[1] WAKE FOREST UNIV,BOWMAN GRAY SCH MED,NEUROSCI PROGRAM,WINSTON SALEM,NC 27103
关键词
CEREBRAL CIRCULATION; HYPERCAPNIA; NEUROTRANSMITTERS; RABBITS;
D O I
10.1161/01.STR.24.11.1740
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Purpose: We examined responses of rabbit pial arterioles to three different stimuli before and after induction of cortical spreading depression. Methods: In urethane-anesthetized rabbits equipped with a closed cranial window, we measured pial arteriolar diameter during baseline conditions, topical application of calcitonin gene-related peptide (CGRP), topical application of acetylcholine, and inhalation of 10% CO2 in air (arterial hypercapnia) before cortical spreading depression and 30, 60, and 120 minutes after cortical spreading depression. Cortical spreading depression was induced by localized application of a 5% KCl solution anterior to the arteriole being measured. Results: Average baseline diameter was approximately 90 mum. During cortical spreading depression, arteriolar diameter increased to a peak value that was 50+/-4% above baseline (n=32). Before cortical spreading depression, arteriolar diameter changed 47+/-7% (n=9) during hypercapnia, 17+/-3% (n=4) during 10(-9) mol/L CGRP, 42+/-10% (n=7) during 10(-7) mol/L CGRP, 29+/-6% (n=4) during 10(-6) mol/L acetylcholine, and 61+/-13% (n=6) during 10(-4) mol/L acetylcholine. Arteriolar responsiveness to any of these stimuli was not changed significantly by prior cortical spreading depression. Conclusions: Dilator capacity of pial arterioles is still intact in urethane-anesthetized rabbits after cortical spreading depression.
引用
收藏
页码:1740 / 1745
页数:6
相关论文
共 25 条
  • [1] MECHANISM OF EFFECT OF HYPERCAPNIC ACIDOSIS ON RENIN SECRETION IN THE DOG
    ANDERSON, RJ
    ROSE, CE
    BERNS, AS
    ERICKSON, AL
    ARNOLD, PE
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1980, 238 (02): : F119 - F125
  • [2] BURES J, 1974, MECHANISM APPLICATIO
  • [3] BURESOVA O, 1957, PHYSIOL BOHEMOSLOV, V6, P159
  • [4] SELECTIVE ATTENUATION BY PERIVASCULAR BLOOD OF PROSTANOID-DEPENDENT CEREBROVASCULAR DILATION IN PIGLETS
    BUSIJA, DW
    LEFFLER, CW
    [J]. STROKE, 1991, 22 (04) : 484 - 488
  • [5] PERIVASCULAR PEPTIDES RELAX CEREBRAL-ARTERIES CONCOMITANT WITH STIMULATION OF CYCLIC ADENOSINE-MONOPHOSPHATE ACCUMULATION OR RELEASE OF AN ENDOTHELIUM-DERIVED RELAXING FACTOR IN THE CAT
    EDVINSSON, L
    FREDHOLM, BB
    HAMEL, E
    JANSEN, I
    VERRECCHIA, C
    [J]. NEUROSCIENCE LETTERS, 1985, 58 (02) : 213 - 217
  • [7] THE EFFECT OF MK-801 ON CORTICAL SPREADING DEPRESSION IN THE PENUMBRAL ZONE FOLLOWING FOCAL ISCHEMIA IN THE RAT
    GILL, R
    ANDINE, P
    HILLERED, L
    PERSSON, L
    HAGBERG, H
    [J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1992, 12 (03) : 371 - 379
  • [8] RELATIONSHIP BETWEEN LOCAL CHANGES IN CORTICAL BLOOD-FLOW AND EXTRACELLULAR K+ DURING SPREADING DEPRESSION
    HANSEN, AJ
    QUISTORFF, B
    GJEDDE, A
    [J]. ACTA PHYSIOLOGICA SCANDINAVICA, 1980, 109 (01): : 1 - 6
  • [9] CELLULAR MECHANISM OF FORCE DEVELOPMENT IN CAT MIDDLE CEREBRAL-ARTERY BY REDUCED PSO2
    HARDER, DR
    MADDEN, JA
    [J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1985, 403 (04): : 402 - 406
  • [10] LOCAL MECHANISM OF CO2 ACTION ON CAT PIAL ARTERIOLES
    KONTOS, HA
    WEI, EP
    RAPER, AJ
    PATTERSON, JL
    [J]. STROKE, 1977, 8 (02) : 226 - 229