THE AMPA RECEPTOR ANTAGONIST NBQX DOES NOT ALTER THE MOTOR RESPONSE INDUCED BY SELECTIVE DOPAMINE AGONISTS IN MPTP-TREATED MONKEYS

被引：40

作者：

LUQUIN, MR

OBESO, JA

LAGUNA, J

GUILLEN, J

MARTINEZLAGE, JM

机构：

[1] Department of Neurology, Clínica Universitaria de Navarra, Medical School, Pamplona

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 235卷 / 2-3期

关键词：

AMPA RECEPTORS; NBQX(2,3-DIHYDROXY-6-NITRO-7-SULFAMOYLBENZO[F]QUINOXALINE(1H,4H)DIONE SODIUM SALT); PARKINSONISM; DYSKINESIA; DOPAMINE RECEPTOR AGONISTS;

D O I：

10.1016/0014-2999(93)90149-C

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We studied the motor response induced by the administration of the AMPA receptor antagonist, NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]quinoxaline(1H,4H)dione sodium salt), in two parkinsonian monkeys and its interaction with the selective D-2 dopamine receptor agonist, (+)-PHNO [(+)-4-propyl-9-hydroxynaphthoxazine], and the partial dopamine D-1 receptor agonist, CY 208-243 [(-)-4,6,6a,7,8,12b-hexahydro-7-methyl-indolo[4,3a-b]phenanthyxidine]. NBQX treatment did not reverse the parkinsonism or change the responses previously induced by dopamine agonists. These results do not support an antiparkinsonian effect of the AMPA receptor antagonist, NBQX. In addition they indicate that there is no functional interaction between AMPA and dopamine receptors in monkeys with a substantia nigra lesion.

引用

页码：297 / 300

页数：4

共 13 条

[1]

BERGMAN H, 1990, SCIENCE, V249, P1439

[2] ALLEVIATION OF PARKINSONISM BY ANTAGONISM OF EXCITATORY AMINO-ACID TRANSMISSION IN THE MEDIAL SEGMENT OF THE GLOBUS-PALLIDUS IN RAT AND PRIMATE [J].