REPEATED TREATMENT WITH ANTIDEPRESSANT DRUGS PREVENTS SALBUTAMOL-INDUCED HYPOACTIVITY IN RATS

被引：19

作者：

PRZEGALINSKI, E ^{[1
]}

BARAN, L ^{[1
]}

SIWANOWICZ, J ^{[1
]}

BIGAJSKA, K ^{[1
]}

机构：

[1] POLISH ACAD SCI, INST PHARMACOL, 12 SMETNA STREET, PL-31343 CRACOW, POLAND

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1984年 / 21卷 / 05期

关键词：

D O I：

10.1016/S0091-3057(84)80004-0

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

A number of antidepressant drugs, administered repeatedly, prevent the salbutamol-induced hypoactivity in rats. Further experiments show that a similar effect is produced by repeated but not acute treatment with other antidepressants: clomipramine, mianserin and nialamide. Two non-antidepressant psychotropic drugs, haloperidol and diazepam, were inactive after repeated administration. These results seem to support 2 h earlier hypothesis that prevention of the salbutamol-induced hypoactivity may be regarded as functional evidence at the behavioral level for the subsensitivity of .beta.-adrenoceptors.

引用

页码：695 / 698

页数：4

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