EXPRESSION OF NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTOR GENES IN THE DEVELOPING CHICK VISUAL-SYSTEM

被引：65

作者：

MATTER, JM

MATTERSADZINSKI, L

BALLIVET, M

机构：

来源：

EMBO JOURNAL | 1990年 / 9卷 / 04期

关键词：

acetylcholine receptor; chick embryo; optic tectum; synaptogenesis;

D O I：

10.1002/j.1460-2075.1990.tb08205.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Expression of the neuronal non-α nicotinic acetylcholine receptor (nα nAChR) gene is transiently stimulated in the chick optic tectum between embryonic days 7 and 16 with a peak value reached around embryonic day 12. This stimulation takes place at the time when optic nerve axons are invading this region of the brain and proceeds along a rostral to caudal gradient. Transcripts of the nα nAChR gene are localized in the superficial layers of the tectum at the time when cells in these layers are forming synapses with retina axons. The transient expression of nα nAChR gene does not take place in the optic tectum of 'eyeless' embryos. The results of our study suggest that the neuronal nα nAChR gene may play a role in neurogenesis of retino-tectal connections.

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页码：1021 / 1026

页数：6

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