DOSE-RELATED ANALGESIC EFFECTS OF FLUPIRTINE

被引：37

作者：

HUMMEL, T ^{[1
]}

FRIEDMANN, T ^{[1
]}

PAULI, E ^{[1
]}

NIEBCH, G ^{[1
]}

BORBE, HO ^{[1
]}

KOBAL, G ^{[1
]}

机构：

[1] ASTA PHARMA AG,DEPT BIOCHEM,W-6000 FRANKFURT,GERMANY

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1991年 / 32卷 / 01期

关键词：

FLUPIRTINE; EVOKED POTENTIAL; ELECTROENCEPHALOGRAM; PAIN MEASUREMENT; CENTRAL NERVOUS SYSTEM; ANALGESIMETRY; DOSE-RESPONSE RELATIONSHIP;

D O I：

10.1111/j.1365-2125.1991.tb05615.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 Flupirtine is a novel and, in all probability, centrally acting, analgesic. The present investigation was conducted in order to investigate dose-related effects of perorally administered flupirtine in man, with special regard to specifically analgesic actions, employing a model based on pain-related chemosomatosensory evoked potentials and subjective intensity estimates of painful stimuli. 2 Plasma concentrations of flupirtine measured 2 h after dosing linearly increased as a function of the administered dose. 3 It was possible to reproduce our own previously obtained results, which established the analgesic action of 200 mg flupirtine administered perorally. 4 Intensity estimates linearly decreased as a function of the administered dose, whereas chemosomatosensory evoked potential amplitudes non-linearly changed in relation to the administered dose. 5 In the spontaneous EEG, a dose-dependent increment in the power-spectra was observed, and this mainly in the alpha- and beta-range.

引用

页码：69 / 76

页数：8

共 34 条

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