CYCLIC-AMP ANALOG ACTIVATES NA+-DEPENDENT INWARD CURRENTS IN DISSOCIATED FROG MOTONEURONS

被引：2

作者：

ADACHI, S ^{[1
]}

OKA, JI ^{[1
]}

NAGAO, T ^{[1
]}

FUKUDA, H ^{[1
]}

机构：

[1] NIHON UNIV,COLL PHARM,DEPT PHARMACOL,FUNABASHI,CHIBA,JAPAN

来源：

BRAIN RESEARCH | 1992年 / 573卷 / 02期

关键词：

MOTONEURON; CYCLIC AMP; 8-BROMO-CYCLIC AMP; FORSKOLIN; SPINAL CORD; FROG;

D O I：

10.1016/0006-8993(92)90787-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Effects of intracellular accumulation of 3',5'-cyclic adenosine monophosphate (cAMP) were studied using 3',5'-cyclic 8-bromoadenosine monophosphate (8-Br-cAMP) and forskolin on single motoneurons acutely dissociated from adult bullfrog spinal cord. 8-Br-cAMP (10(-3) M) and forskolin (1.5 x 10(-6) M) activated inward currents under K+-free conditions at a holding potential of -70 mV. The currents were dependent on extracellular Na+ concentration, and were never reversed within the range of membrane potentials tested (-130 to 30 mV). These results indicate that accumulation of intracellular cAMP induces Na+-dependent inward currents in frog motoneurons.

引用

页码：349 / 352

页数：4

共 19 条

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