THE USE OF LOSS OF CONSTITUTIONAL HETEROZYGOSITY DATA TO ASCERTAIN THE LOCATION OF PREDISPOSING GENES IN CANCER FAMILIES

被引：12

作者：

TEARE, MD

ROHDE, K

KOREF, MFS

机构：

[1] MAX DELBRUCK CTR MOLEC MED,DEPT BIOINFORMAT,D-13122 BERLIN,GERMANY

[2] CHRISTIE RES CTR,PATERSON INST CANC RES,DEPT CANC GENET,MANCHESTER M20 9BX,LANCS,ENGLAND

来源：

JOURNAL OF MEDICAL GENETICS | 1994年 / 31卷 / 06期

关键词：

D O I：

10.1136/jmg.31.6.448

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A method is described to investigate the inheritance of disease predisposition in cancer families. It is an extension of classic genetic linkage analysis, which enables information on loss of constitutional heterozygosity (LOCH) to be incorporated into the model. This adapted model treats LOCH data as additional observations on the disease phenotype. One of the major benefits of this approach is that isolated parent-offspring pairs are now potentially informative for linkage analysis. Examples are presented.

引用

页码：448 / 452

页数：5

共 11 条

[1] LOSS OF HETEROZYGOSITY ON CHROMOSOME-7Q AND AGGRESSIVE PRIMARY BREAST-CANCER [J].

BIECHE, I ;

CHAMPEME, MH ;

MATIFAS, F ;

HACENE, K ;

CALLAHAN, R ;

LIDEREAU, R .

LANCET, 1992, 339 (8786) :139-143

[2]

BIRCH JM, 1994, CANCER RES, V54, P1

[3] LOSS OF HETEROZYGOSITY, CHROMOSOME-7Q, AND BREAST-CANCER [J].

CORNELISSE, CJ .

LANCET, 1992, 339 (8806) :1423-1423

[4]

DEVILEE P, 1991, ONCOGENE, V6, P1705

[5]

EASTON DF, 1993, AM J HUM GENET, V52, P78

[6] MUTATION AND CANCER - STATISTICAL STUDY OF RETINOBLASTOMA [J].

KNUDSON, AG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1971, 68 (04) :820-&

[7]

KOREF MS, 1991, LANCET, V338, P1490

[8]

LUSTBADER ED, 1992, AM J HUM GENET, V51, P344

[9]

OTT J, 1985, ANAL HUMAN GENETIC L

[10]

SAITO H, 1993, CANCER RES, V53, P3382

← 1 2 →