A CARCINOGENICITY STUDY OF STYRENE-7,8-OXIDE IN RATS

被引：43

作者：

PONOMARKOV, V ^{[1
]}

CABRAL, JRP ^{[1
]}

WAHRENDORF, J ^{[1
]}

GALENDO, D ^{[1
]}

机构：

[1] INT AGCY RES CANC, 150 COURS ALBERT THOMAS, F-69372 LYON 08, FRANCE

来源：

CANCER LETTERS | 1984年 / 24卷 / 01期

关键词：

D O I：

10.1016/0304-3835(84)90085-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Styrene-7,8-oxide (200 mg/kg body wt) was given orally to female BDIV rats on day 17 of pregnancy. Their offspring received 96 weekly doses of styrene oxide (100-150 mg/kg body wt). Following the continuous administration of styrene oxide, an increased incidence, statistically significant, of forestomach tumors was observed in rats of both sexes. The incidence of tumors occurring at other sites was similar in treated and control animals. Styrene oxide appparently is a direct-acting carcinogen producing benign and malignant tumors of the forestomach.

引用

页码：95 / 101

页数：7

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