EFFECTS OF L-156,602, A C5A RECEPTOR ANTAGONIST, ON MOUSE EXPERIMENTAL-MODELS OF INFLAMMATION

被引：16

作者：

TSUJI, RF

MAGAE, J

NAGAI, K

YAMASAKI, M

机构：

[1] TOKYO INST TECHNOL, DEPT BIOENGN, MIDORI KU, YOKOHAMA, KANAGAWA 227, JAPAN

[2] UNIV TOKYO, DEPT AGR CHEM, IMMUNOPATHOL, TOKYO 113, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1992年 / 56卷 / 12期

关键词：

D O I：

10.1271/bbb.56.2034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

L-156,602, a C5a receptor antagonist, was found as an immunosuppressant with preferential effects on delayed-type hypersensitivity (DTH) in our screening program and it was shown that L-156,602 suppressed the efferent phase of DTH. Here, we tested its.effects on experimental models of inflammation induced in mice. L-156,602 did not suppress serotonin- and carrageenan- induced inflammation while it completely suppressed concanavalin A-induced inflammation 4 h after elicitation. The inflammation appeared 24 h after the elicitation with concanavalin A and it was significantly suppressed by L-156,602. Muramyl dipeptide (MDP)-induced acute joint inflammation was also significantly suppressed by L-156,602. These results demonstrated the unique immunomodulating properties of L-156,602 in mouse experimental models of inflammation.

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页码：2034 / 2036

页数：3

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