DUPLICATION-TARGETED DNA METHYLATION AND MUTAGENESIS IN THE EVOLUTION OF EUKARYOTIC CHROMOSOMES

被引：138

作者：

KRICKER, MC

DRAKE, JW

RADMAN, M

机构：

[1] NIEHS,MOLEC GENET LAB,RES TRIANGLE PK,NC 27709

[2] INST JACQUES MONOD,F-75251 PARIS 05,FRANCE

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 03期

关键词：

REPEAT-INDUCED POINT MUTATION; CPG DINUCLEOTIDE;

D O I：

10.1073/pnas.89.3.1075

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mammalian genomes are threatened with gene inactivation and chromosomal scrambling by recombination between repeated sequences such as mobile genetic elements and pseudogenes. We present and test a model for a defensive strategy based on the methylation and subsequent mutation of CpG dinucleotides in those DNA duplications that create uninterrupted homologous sequences longer than about 0.3 kilobases. The model helps to explain both the diversity of CpG frequencies in different genes and the persistence of gene fragmentation into exons and introns.

引用

页码：1075 / 1079

页数：5

共 39 条

[1] HIGH-LEVELS OF DENOVO METHYLATION AND ALTERED CHROMATIN STRUCTURE AT CPG ISLANDS IN CELL-LINES [J].