SYNTHESIS AND PRELIMINARY BIOLOGICAL EVALUATION OF 1-AMINOMETHYL-4-SUBSTITUTED-4H-PYRROLO[2,1-C][1,4] BENZOTHIAZINES, A NEW CLASS OF CALCIUM-ANTAGONISTS

被引：9

作者：

CAMPIANI, G

NACCI, V

GAROFALO, A

BOTTA, M

FIORINI, I

TAFI, A

BRUNI, G

ROMEO, MR

PERES, A

BERTOLLINI, L

机构：

[1] UNIV SIENA,DIPARTIMENTO FARM CHIM TECNOL,BANCHI SOTTO 55,I-53100 SIENA,ITALY

[2] UNIV SIENA,IST FARMACOL,I-53100 SIENA,ITALY

[3] UNIV MILANO,DIPARTIMENTO FISIOL & BIOCHIM GEN,I-20133 MILAN,ITALY

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(00)80212-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The preparation of 4a-g, conformationally rigid calcium channel blockers related to Diltiazem, is described starting from tricyclic compounds 5a-c. On radioreceptor assay and preliminary biochemical tests some compounds show high affinity for Calcium Channel Receptors (CCRs) and calcium antagonistic activity comparable or superior to that of Diltiazem.

引用

页码：1193 / 1198

页数：6

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