GUSTDUCIN IS A TASTE-CELL-SPECIFIC G-PROTEIN CLOSELY RELATED TO THE TRANSDUCINS

被引：533

作者：

MCLAUGHLIN, SK ^{[1
]}

MCKINNON, PJ ^{[1
]}

MARGOLSKEE, RF ^{[1
]}

机构：

[1] ROCHE RES CTR, ROCHE INST MOLEC BIOL, NUTLEY, NJ 07110 USA

来源：

NATURE | 1992年 / 357卷 / 6379期

关键词：

D O I：

10.1038/357563a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A novel G protein alpha-subunit (alpha-gustducin) has been identified and cloned from taste tissue. Alpha-gustducin messenger RNA is expressed in taste buds of all taste papillae (circumvallate, foliate and fungiform); it is not expressed in non-sensory portions of the tongue, nor is it expressed in the other tissues examined. Alpha-gustducin most closely resembles the transducins (the rod and cone photoreceptor G proteins), suggesting that gustducin's role in taste transduction is analogous to that of transducin in light transduction.

引用

页码：563 / 569

页数：7

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