VITREORETINAL TOXICITY OF BASIC FIBROBLAST GROWTH-FACTOR

被引：25

作者：

BORHANI, H ^{[1
]}

PEYMAN, GA ^{[1
]}

RAHIMY, MH ^{[1
]}

BEUERMAN, RW ^{[1
]}

机构：

[1] LOUISIANA STATE UNIV,MED CTR,SCH MED,LSU EYE CTR,2020 GRAVIER STR,SUITE B,NEW ORLEANS,LA 70112

来源：

INTERNATIONAL OPHTHALMOLOGY | 1993年 / 17卷 / 04期

关键词：

BASIC FIBROBLAST GROWTH FACTOR; ELECTRORETINOGOGRAPHY; INTRAVITREAL B-FGF INJECTION; RETINAL TOXICITY; VITREORETINAL PATHOLOGY;

D O I：

10.1007/BF01007740

中图分类号：

R77 [眼科学];

学科分类号：

100212 [眼科学];

摘要：

Basic fibroblast growth factor (b-FGF) is one of the multifunctional growth factors with important therapeutic potential in the field of ophthalmology. It is also implicated in pathogenesis of vitreoretinal proliferative diseases. In the present study, we evaluated its vitreoretinal toxicity by means of clinical observation, electroretinography (ERG), and histopathology after injection of different doses of b-FGF into the vitreous of rabbit eyes. Doses of b-FGF up to 2 mug per eye caused no toxicity; however, injection of 4 mug or more resulted in sight-threatening vitreoretinal proliferative changes. This information is important for studies aimed at evaluating the therapeutic potential of b-FGF in retinal diseases. Despite some degree of vitreous organization and opacification, retinal folds, and small areas of traction retinal detachment, the amplitudes of ERGs were normal or even increased (hyperpolarization) in eyes which received 8 mug of b-FGF.

引用

页码：195 / 199

页数：5

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